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Data from this study suggest Vitamin D for breast cancer prevention
Department of Medicine, Division of Hematology/Oncology,
Columbia University, New York, New York 10032, USA.
Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009
May 26.
Association between plasma 25-hydroxyvitamin D and breast
cancer risk.
Crew
KD, Gammon
MD, Steck
SE, Hershman
DL, Cremers
S, Dworakowski
E, Shane
E, Terry
MB, Desai
M, Teitelbaum
SL, Neugut
AI, Santella
RM.
Vitamin D has been associated with decreased risk of several
cancers. In experimental studies, vitamin D has been shown
to inhibit cell proliferation and induce differentiation and
apoptosis in normal and malignant breast cells. Using a population-based
case-control study on Long Island, New York, we examined the
association of breast cancer with plasma 25-hydroxyvitamin
D (25-OHD) levels, a measure of vitamin D body stores. In-person
interviews and blood specimens were obtained from 1,026 incident
breast cancer cases diagnosed in 1996 to 1997 and 1,075 population-based
controls. Plasma 25-OHD was measured in batched, archived
specimens by Diasorin RIA. The mean (SD) plasma 25-OHD concentration
was 27.1 (13.0) and 29.7 (15.1) ng/mL in the cases and controls,
respectively (P < 0.0001). Plasma 25-OHD was inversely
associated with breast cancer risk in a concentration-dependent
fashion (P(trend) = 0.002). Compared with women with vitamin
D deficiency (25-OHD, <20 ng/mL), levels above 40 ng/mL
were associated with decreased breast cancer risk (odds ratio,
0.56; 95% confidence interval, 0.41-0.78). The reduction in
risk was greater among postmenopausal women (odds ratio, 0.46;
95% confidence interval, 0.09-0.83), and the effect did not
vary according to tumor hormone receptor status. In summary,
these results add to a growing body of evidence that adequate
vitamin D stores may prevent breast cancer development. Whereas
circulating 25-OHD levels of >32 ng/mL are associated with
normal bone mineral metabolism, our data suggest that the
optimal level for breast cancer prevention is >or=40 ng/mL.
Well-designed clinical trials are urgently needed to determine
whether vitamin D supplementation is effective for breast
cancer chemoprevention.
PMID: 19470790 [PubMed - indexed for MEDLINE
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